Introduction:
Apranax tablet is a nonsteroidal anti-inflammatory drug (NSAID) widely used for pain relief and inflammation reduction. It is effective in treating conditions such as arthritis, muscle pain, menstrual cramps, and headaches. Naproxen sodium works by reducing hormones that cause inflammation and pain in the body. Unlike other pain relievers like acetaminophen, it targets inflammation more directly, making it especially useful in managing chronic inflammatory conditions.
How does Apranax tablet work?
Mechanism of Action:
Apranax tablet inhibits cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. These enzymes are responsible for the production of prostaglandins, which are chemicals that promote inflammation, pain, and fever. By blocking these enzymes, naproxen sodium reduces the level of prostaglandins, thus diminishing inflammation and alleviating pain.
Apranax tablet uses
Osteoarthritis
Rheumatoid arthritis
Ankylosing spondylitis
Gout (acute flare-ups)
Tendonitis and bursitis
Primary dysmenorrhea (menstrual cramps)
Acute pain from strains and sprains
Apranax tablet Dosage:
Adults: Typical dosage is 220 mg to 550 mg every 12 hours, depending on the severity of pain or inflammation. For acute pain, an initial higher dose (up to 825 mg) may be taken, followed by maintenance doses.
Maximum Daily Dose: 1,375 mg per day is generally recommended as the upper limit to avoid adverse effects.
Children (12 years and older): 220 mg every 8 to 12 hours, with a maximum of 660 mg per day.
Geriatric Use: In older adults, a lower dose and close monitoring are advised due to an increased risk of gastrointestinal and cardiovascular side effects.
Off-label Uses:
Migraine prevention and treatment
Postoperative pain management (as part of multi-modal pain control)
Prophylaxis against kidney stone recurrence due to its ability to reduce inflammation in the urinary tract
Menstrual disorders beyond dysmenorrhea, such as endometriosis-associated pain
Apranax tablet Side Effects:
Common side effects:
- Nausea,
- heartburn,
- indigestion,
- dizziness
- drowsiness
Serious side effects:
Gastrointestinal bleeding or ulcers, especially in older adults or those with a history of ulcers
Increased risk of cardiovascular events (heart attack, stroke)
Kidney dysfunction, particularly in those with pre-existing renal issues or chronic use
Elevated blood pressure
Warnings and Precautions:
Cardiovascular Risk: Naproxen sodium may increase the risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke. This risk is higher with long-term use or in patients with pre-existing heart disease.
Gastrointestinal Risk: Prolonged use can result in serious gastrointestinal adverse effects like bleeding, ulcers, and perforation of the stomach or intestines. These complications can occur without warning and are more likely in the elderly.
Renal and Hepatic Effects: Use naproxen sodium cautiously in patients with impaired kidney or liver function, as it may cause further deterioration of these organs.
Asthma and Allergic Reactions: People with aspirin-sensitive asthma may have a higher likelihood of experiencing severe allergic reactions, such as anaphylaxis, when using NSAIDs like naproxen sodium.
Pregnancy and Breastfeeding: It is advised to avoid naproxen sodium during the third trimester of pregnancy due to the risk of premature closure of the ductus arteriosus in the fetus. Its use in breastfeeding should be discussed with a healthcare provider.
Important Insstruction Not Widely Known:
Dual Action on Platelets: While it does not have the strong blood-thinning properties of aspirin, it can still affect platelet function, leading to a slight increase in bleeding time. This makes it crucial to avoid in patients undergoing surgery or those on anticoagulant therapy.
Tinnitus Risk: High doses of naproxen sodium, especially if taken long term, can lead to tinnitus (ringing in the ears), which might signal early signs of toxicity.
Reduced Absorption with Antacids: While antacids may help alleviate stomach upset caused by naproxen sodium, they can also reduce its absorption and effectiveness if taken together. It is recommended to separate their intake by at least 1-2 hours.
Use in Sports Injuries: Though Apranax tablet is widely used for muscle and joint pain, it may delay healing in soft tissue injuries (such as sprains or ligament damage) by inhibiting prostaglandin-driven inflammatory responses that play a role in tissue repair.
Warnings for Special Populations:
Elderly:
Due to the increased risk of serious gastrointestinal and cardiovascular events, elderly patients should be prescribed the lowest effective dose for the shortest possible duration
Liver Cirrhosis Patients:
In patients with advanced liver disease or cirrhosis, Apranax tablet should be used cautiously as it can exacerbate liver damage and increase the risk of gastrointestinal complications.
Storage
Store it at room temperature, away from moisture and direct sunlight.
Keep out of reach of children, and ensure the bottle or blister packaging is tightly sealed.
Avoid storing in bathrooms or humid environments as it may degrade the active ingredient.
Disclaimer:
This article is only for information purposes only. Please don’t take it as a medical advice.