Clopidogrel is an antiplatelet medicine. It keeps platelets from sticking together, which lowers the risk of blood clots. Doctors prescribe it to people who have had a heart attack, a stroke, or a stent placed in an artery.
What Is Clopidogrel Used For?
- Preventing heart attack and stroke in people with heart disease or peripheral artery disease
- Treating acute coronary syndrome
- Protecting a coronary stent from clots
- Preventing a second stroke
How Does Clopidogrel Work?
Clopidogrel blocks a receptor on platelets called P2Y12. Platelets then cannot clump together, and clots are less likely to form. Your liver must first change clopidogrel into its active form.
General Dosage Information
This is general information only. Your doctor sets the right dose for you, so follow your prescription and the label.
- Adults usually take 75 mg once a day. In an emergency, doctors may give a larger starting dose of 300 mg to 600 mg.
- Take it at the same time each day, with or without food.
- Do not stop it on your own, especially after a stent. Stopping early can cause a clot.
Side Effects of Clopidogrel
Common Side Effects
- Easy bruising
- Nosebleeds
- Stomach upset or diarrhea
- Rash or itching
Serious Side Effects
Call your doctor or get emergency help if you notice:
- Bleeding that does not stop
- Black stools or vomiting blood
- Sudden severe headache or confusion
- Fever, weakness, and unusual bruising, which can signal a rare blood problem
Who Should Be Cautious?
- People with active bleeding, such as a stomach ulcer
- People with liver disease
- People who plan surgery or dental work, who should tell their surgeon or dentist
- Some people who cannot change clopidogrel into its active form because of their genes
Drug Interactions
Tell your doctor and pharmacist about every medicine and supplement you take. Examples of important interactions include:
- Omeprazole and esomeprazole: they can lower the effect of clopidogrel.
- Warfarin and other blood thinners: together they raise the risk of bleeding.
- NSAIDs such as ibuprofen: they raise the risk of stomach bleeding.
- Aspirin: doctors sometimes prescribe both on purpose, so follow their advice.
Storage and Precautions
- Store it at room temperature, away from heat, light, and moisture.
- Keep it out of the reach of children.
Frequently Asked Questions
When should I stop before surgery?
Only your doctor can tell you. Do not stop it on your own.
Why am I bruising more?
Clopidogrel makes bleeding and bruising easier.
Can I take painkillers?
Paracetamol is usually safer than NSAIDs. Ask your doctor.
Disclaimer: This article is for information only. It is not medical advice. Please talk to your doctor about your own health.