Domperidone is a medicine for nausea, vomiting, and a feeling of fullness or bloating. It helps your stomach and gut move food along. Because it can affect heart rhythm, doctors use the lowest dose for the shortest time.
What Is Domperidone Used For?
- Nausea and vomiting
- Bloating and early fullness after meals
- Upper abdominal discomfort linked to slow stomach emptying
How Does Domperidone Work?
Domperidone blocks dopamine receptors in the gut and in the area of the brain that triggers vomiting. This helps the stomach empty faster and calms nausea.
General Dosage Information
This is general information only. Your doctor sets the right dose for you, so follow your prescription and the label.
- Adults usually take 10 mg up to three times a day, 15 to 30 minutes before meals. Do not take more than 30 mg a day.
- Most people should not take it for longer than about one week without a doctor’s review.
- Doctors dose children by weight and use it rarely.
Side Effects of Domperidone
Common Side Effects
- Dry mouth
- Headache
- Diarrhea or stomach cramps
- Breast tenderness or milk production, because it raises prolactin
Serious Side Effects
Call your doctor or get emergency help if you notice:
- Fast, irregular, or pounding heartbeat, or fainting
- Severe dizziness
- Signs of an allergic reaction
Who Should Be Cautious?
- People with heart disease or heart rhythm problems
- People with moderate to severe liver disease
- People with low potassium or magnesium
- Older adults
- Pregnant or breastfeeding women should ask their doctor
Drug Interactions
Tell your doctor and pharmacist about every medicine and supplement you take. Examples of important interactions include:
- Ketoconazole, erythromycin, and clarithromycin: they raise domperidone levels and heart risk, so doctors avoid them together.
- Other medicines that affect heart rhythm: together they raise the risk of dangerous rhythm problems.
- Antacids and acid reducers: they can lower domperidone absorption, so take them after meals.
Storage and Precautions
- Store it at room temperature, away from heat, light, and moisture.
- Keep it out of the reach of children.
Frequently Asked Questions
When should I take it?
Take it before meals.
Is it safe for the heart?
It carries a small risk, so doctors use the lowest dose for the shortest time.
Can I take it for a long time?
Only if your doctor advises it.
Disclaimer: This article is for information only. It is not medical advice. Please talk to your doctor about your own health.