Simvastatin is a statin that lowers cholesterol and reduces the risk of heart attack and stroke. Doctors have used it for many years.
What Is Simvastatin Used For?
- High LDL (“bad”) cholesterol
- High triglycerides
- Lowering the risk of heart attack and stroke
- Inherited high cholesterol
How Does Simvastatin Work?
Simvastatin blocks an enzyme called HMG-CoA reductase, which your liver uses to make cholesterol. Your body makes most cholesterol at night, so doctors usually advise taking it in the evening.
General Dosage Information
This is general information only. Your doctor sets the right dose for you, so follow your prescription and the label.
- Adults usually take 10 mg to 40 mg once a day in the evening.
- Doctors no longer start people on 80 mg, because the risk of muscle damage is higher.
- Your doctor may check your liver and cholesterol with blood tests.
Side Effects of Simvastatin
Common Side Effects
- Muscle aches
- Headache
- Stomach pain, constipation, or gas
- Nausea
Serious Side Effects
Call your doctor or get emergency help if you notice:
- Severe muscle pain, weakness, or dark urine
- Yellow skin or eyes
- Severe stomach pain
Who Should Be Cautious?
- Pregnant or breastfeeding women, who should not take it
- People with liver disease
- People with kidney disease
- Older adults and people with an underactive thyroid, who face a higher risk of muscle problems
Drug Interactions
Tell your doctor and pharmacist about every medicine and supplement you take. Examples of important interactions include:
- Amlodipine: doctors limit simvastatin to 20 mg a day.
- Diltiazem and verapamil: doctors limit simvastatin to 10 mg a day.
- Clarithromycin, itraconazole, and ketoconazole: do not combine them with simvastatin.
- Gemfibrozil: do not combine it with simvastatin.
- Grapefruit juice: avoid large amounts.
Storage and Precautions
- Store it at room temperature, away from heat, light, and moisture.
- Keep it out of the reach of children.
Frequently Asked Questions
Why do I take it in the evening?
Your liver makes more cholesterol at night.
Can I take it with amlodipine?
Yes, but your doctor limits the simvastatin dose.
How long until it works?
Cholesterol usually drops within four to six weeks.
Disclaimer: This article is for information only. It is not medical advice. Please talk to your doctor about your own health.