Fluoxetine is an SSRI antidepressant. Doctors prescribe it for depression, obsessive-compulsive disorder, and bulimia nervosa. It stays in the body for a long time, so missed doses cause fewer problems than with other antidepressants.
What Is Fluoxetine Used For?
- Major depression
- Obsessive-compulsive disorder (OCD)
- Bulimia nervosa
- Panic disorder
- Premenstrual dysphoric disorder (PMDD)
How Does Fluoxetine Work?
Fluoxetine blocks the reabsorption of serotonin in the brain. More serotonin stays available, which improves mood and reduces anxiety. Full effects can take four to six weeks.
General Dosage Information
This is general information only. Your doctor sets the right dose for you, so follow your prescription and the label.
- Adults usually start with 20 mg once a day in the morning. Doctors may raise it to 40 mg or 60 mg a day.
- Doctors may start children from age 8 with a lower dose for depression.
- Do not stop it suddenly.
Side Effects of Fluoxetine
Common Side Effects
- Nausea
- Headache
- Trouble sleeping or tiredness
- Nervousness and anxiety early in treatment
- Loss of appetite
Serious Side Effects
Call your doctor or get emergency help if you notice:
- New or worse thoughts of harming yourself, especially in young people. Get help right away.
- Agitation, fever, fast heartbeat, or muscle stiffness, which can signal serotonin syndrome
- Unusual bleeding
- Seizures
Who Should Be Cautious?
- Young people under 25 at the start of treatment
- People with bipolar disorder
- People with liver disease or epilepsy
- People with diabetes, because it can change blood sugar
- Pregnant or breastfeeding women should ask their doctor
Drug Interactions
Tell your doctor and pharmacist about every medicine and supplement you take. Examples of important interactions include:
- MAO inhibitors: do not take them together, or within five weeks of stopping fluoxetine.
- Tamoxifen: fluoxetine can lower its effect.
- Pimozide and thioridazine: do not combine them with fluoxetine.
- Warfarin and NSAIDs: they raise the risk of bleeding.
- Tramadol and triptans: they raise the risk of serotonin syndrome.
Storage and Precautions
- Store it at room temperature, away from heat, light, and moisture.
- Keep it out of the reach of children.
Frequently Asked Questions
Why do I take it in the morning?
It can cause trouble sleeping in some people.
Why is stopping easier than with other SSRIs?
It leaves the body slowly, so withdrawal is usually milder.
Is it safe in teenagers?
Doctors use it carefully in young people and watch closely for mood changes.
Disclaimer: This article is for information only. It is not medical advice. Please talk to your doctor about your own health.