Sertraline is a selective serotonin reuptake inhibitor (SSRI). Doctors prescribe it for depression and several anxiety disorders. It is one of the most widely used antidepressants.
What Is Sertraline Used For?
- Major depression
- Panic disorder
- Obsessive-compulsive disorder (OCD)
- Post-traumatic stress disorder (PTSD)
- Social anxiety disorder
- Premenstrual dysphoric disorder (PMDD)
How Does Sertraline Work?
Sertraline blocks the reabsorption of serotonin in the brain. More serotonin stays available, which helps improve mood and reduce anxiety. It usually takes two to four weeks to feel the full effect.
General Dosage Information
This is general information only. Your doctor sets the right dose for you, so follow your prescription and the label.
- Adults usually start with 25 mg to 50 mg once a day. The usual range is 50 mg to 200 mg a day.
- Take it at the same time each day, with or without food.
- Do not stop it suddenly. Your doctor will lower the dose slowly.
Side Effects of Sertraline
Common Side Effects
- Nausea and diarrhea
- Headache and dizziness
- Trouble sleeping or sleepiness
- Dry mouth and sweating
- Sexual problems, such as lower desire
Serious Side Effects
Call your doctor or get emergency help if you notice:
- New or worse thoughts of harming yourself, especially in the first weeks or in young people. Get help right away.
- Agitation, fever, fast heartbeat, or muscle stiffness, which can signal serotonin syndrome
- Unusual bleeding or bruising
- Very low sodium: confusion, headache, or weakness, mainly in older adults
Who Should Be Cautious?
- Young people under 25, who need close monitoring at the start
- People with bipolar disorder
- People with liver disease or epilepsy
- Pregnant or breastfeeding women should ask their doctor
Drug Interactions
Tell your doctor and pharmacist about every medicine and supplement you take. Examples of important interactions include:
- MAO inhibitors: do not take them together.
- Tramadol, triptans, and other antidepressants: they raise the risk of serotonin syndrome.
- NSAIDs and warfarin: they raise the risk of bleeding.
- Alcohol: it can worsen side effects and mood.
Storage and Precautions
- Store it at room temperature, away from heat, light, and moisture.
- Keep it out of the reach of children.
Frequently Asked Questions
How long until it works?
Many people notice some improvement in two weeks, with full benefit after four to six weeks.
Can I stop it when I feel better?
Keep taking it as long as your doctor advises, then stop slowly.
Does it cause weight gain?
Some people gain a little weight with long use.
Disclaimer: This article is for information only. It is not medical advice. Please talk to your doctor about your own health.